What is the risk associated with elevated levels of iPTH?

Elevated levels of iPTH, or intact parathyroid hormone, are primarily associated with bone deterioration. The hormone regulates calcium levels in the blood and is critical for maintaining bone health. When iPTH is elevated, it typically indicates that the body is responding to low calcium levels, leading to increased bone resorption. This means that the body may begin to break down bone tissue more than it should in order to release calcium into the bloodstream. Over time, this can result in conditions such as osteitis fibrosa cystica or osteoporosis, where bones become weak and brittle.

Proper calcium and phosphorus balance is crucial for maintaining healthy bones, and when parathyroid hormone levels are out of balance, it can directly impact bone integrity, leading to increased risk of fractures and other bone-related complications. Understanding the role of iPTH in these processes highlights the importance of monitoring and managing these hormone levels to prevent bone health issues.